Attenuation of early atherosclerotic lesions by immunotolerance with β2 glycoprotein I and the immunomodulatory effectors interleukin 2 and 10 in a murine model

This report shows the effect of cellular autoimmune response inhibition after immunization with β2-glycoprotein I and the effect of immunomodulation with interleukin (IL)-2 and IL-10 in the development of early atherosclerotic vascular lesion in a murine model, concluding that the immunotolerance induction against β2-glycoprotein I attenuates the development of atherosclerosis through downregulation of cellular autoimmune response provoked by IL-2 and IL-10. The novel results drawn from this preclinical in vivo study provide substantial information regarding atherosclerosis pathogeny and a potential clinical application in the near future.