Hypercholesterolemia inhibits re-endothelialization of arterial injuries by TRPC channel activation

Arterial injury after coronary and peripheral arterial angioplasty and stenting is associated with oxidative stress. Oxidized lipids activate a cascade of TRPC channels, leading to an influx of calcium ions and impaired endothelial healing. Deficiency of TRPC6 or TRPC5 channels is associated with preservation of migration. Inhibition of TRPC channel activation after arterial intervention improves endothelial healing, which should decrease luminal thrombogenicity and intimal hyperplasia at the site of an intervention.