Relationship of body fat weight and body fat ratio determined by bioelectric impedance to serum adipocytokines in patients with type 2 diabetes mellitus

SummaryObjectiveVarious adipocytokines are closely associated with both obesity and insulin resistance. We investigated how body fat weight (BFW) and body fat ratio (BFR) affected serum adipocytokines in patients with type 2 diabetes mellitus.MethodsStudies were conducted in type 2 diabetic patients (n = 41) and age-matched healthy subjects (n = 18). BFW and BFR were determined using a high-frequency bioelectric impedance method. We measured the adipocytokines such as leptin, adiponectin, and tumor necrosis factor (TNF)-α in serum.ResultsBFW and BFR showed significant positive correlations with BMI and serum leptin concentrations in diabetic patients. A significant positive correlation was found between BFW and serum FFA. Multivariate analysis identified only BMI a significant independent determinant of BFW. Stepwise analysis disclosed a significant positive correlation between HOMA-R and serum leptin.ConclusionsIn diabetic patients, accumulation of body fat may increase serum leptin and FFA, which in turn would contribute to insulin resistance.

► We investigated how body fat weight (BFW) and body fat ratio (BFR) affected serum adipocytokines in patients with type 2 diabetes mellitus.
► In the present study, a significant positive correlation was found between BFW and serum FFA and multivariate analysis identified only BMI a significant independent determinant of BFW.
► We concluded that in diabetic patients, accumulation of body fat may increase serum leptin and FFA.