کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3004444 1180841 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of obesity on TAFI in postmenopausal period
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of obesity on TAFI in postmenopausal period
چکیده انگلیسی

SummaryAimThe aim of the study was to evaluate how obesity effects the coagulation and fibrinolytic system in the postmenopausal period.MethodForty-eight obese (body mass index (BMI) ≥30 kg/m2) and 38 nonobese (BMI < 30 kg/m2) postmenopausal women were enrolled in the study. Fat mass and insulin resistance were calculated. Plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), d-dimer, thrombomodulin, and thrombin activatable fibrinolysis inhibitor (TAFI) antigen were determined by ELISA method. TAFI activity was measured using the chromogenic assay.ResultsObese subjects had higher PAI-1 (73.5 ± 35.7 ng/mL vs. 57.1 ± 34.2 ng/mL, p < 0.05) levels but lower tPA/PAI-1 ratio (0.59 ± 0.50 vs. 38 ± 0.21, p < 0.05) than their nonobese counterparts. Obesity was not statistically significant for other haemostatic variables. BMI and fat mass were positively correlated with PAI-1 (r = 0.312, p = 0.003; r = 0.381, p = 0.005, respectively) and negatively correlated with tPA/PAI-1 ratio (r = −0.273, p = 0.01; r = −0.545, p = 0.01, respectively). HOMA scores were also positively correlated with PAI-1 levels (r = 0.236, p = 0.04).ConclusionWe found that tendency to hypercoagulability in the postmenopausal women was due to increased PAI-1 rather than TAFI levels, which may contribute to adverse cardiovascular outcomes in this cohort. Further studies should be undertaken to evaluate effects of weight loss on the coagulation and fibrinolytic system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Obesity Research & Clinical Practice - Volume 4, Issue 4, October–December 2010, Pages e271–e276
نویسندگان
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