کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3004601 | 1180846 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adverse effects of obesity on β-cell function in Japanese subjects with normal glucose tolerance
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The purpose of the present study was to elucidate the role of obesity in both early- and late-phase insulin secretion during an oral glucose tolerance test (OGTT) performed with 75 g glucose in Japanese subjects. This was performed using indices of β-cell function adjusted for insulin sensitivity. Of 155 subjects assessed, 68 had normal glucose tolerance (NGT) and 87 had impaired glucose tolerance (IGT). We used the homeostasis model assessment-insulin resistance (HOMA-IR) index as an indicator of insulin sensitivity. As indicators of β-cell function, we used the HOMA-β index, an insulinogenic index (ÎI30/ÎG30), and ÎAUC I/G(0-120), which were obtained in the OGTT. We then reevaluated the results after adjusting the β-cell function for insulin sensitivity ([ÎI30/ÎG30]/HOMA-IR index and [ÎAUC I/G(0-120)]/HOMA-IR index). β-Cell function was observed to reduce as the glucose tolerance deteriorated from NGT to IGT. However, when the effects of obesity were considered, the obese subjects with NGT already showed a decline in the (ÎAUC I/G(0-120))/HOMA-IR index value when compared with the nonobese subjects with NGT, despite the fact these subjects did not differ with regard to (ÎI30/ÎG30)/HOMA-IR index. As the glucose tolerance deteriorated to IGT, both (ÎI30/ÎG30)/HOMA-IR index and (ÎAUC I/G(0-120))/HOMA-IR index decreased to an identical extent in both subgroups. These data indicate that obesity causes a decrease in insulin secretion, especially during the late phase following a glucose load, even if the glucose tolerance remains normal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Obesity Research & Clinical Practice - Volume 2, Issue 3, September 2008, Pages 195-202
Journal: Obesity Research & Clinical Practice - Volume 2, Issue 3, September 2008, Pages 195-202
نویسندگان
Yuko Akehi, Keizo Anzai, Hitoshi Katsuta, Ryoko Yoshida, Kumiko Ohkubo, Takaaki Yamashita, Hironobu Kawashima, Junko Ono,