Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant

Highlight
• Adipokines, MMP2 and TIMP2 levels are increased in preeclampsia patients.
• Adiponectin may contribute to the higher levels of MMP2 and TIMP2 in preeclampsia.
• Adiponectin, MMP2 and TIMP2 may have a role in the pathophysiology in preeclampsia.

ObjectiveThe aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them.MethodsA total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽30 kg/m2 were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs.ResultsAdiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP.ConclusionOur findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease.