کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3008852 1181467 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats
چکیده انگلیسی

ObjectivesThe main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA4-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats.MethodsThirty two adult male rats were randomized to sham group (sham), haemorrhagic shock/resuscitation (HS), HS plus BML-111 (BML-111), and HS plus BML-111 and BOC-2 (BOC-2). Haemorrhagic shock was induced by blood drawing, and then resuscitation was obtained by infusion of shed blood and two-fold volume saline.ResultsHistological findings, as well as assays of neutrophilic infiltration (myeloperoxidase activity, ICAM-1 expression), inflammatory cytokines and pro-inflammatory factor (IκB-α and NF-κB p65) confirmed that haemorrhagic shock induced acute lung injury. BML-111 significantly mitigated acute lung injury induced by haemorrhagic shock. However, BOC-2, an antagonist of the lipoxinA4-receptor, partially reversed the protective effect of BML-111 on the haemorrhagic shock-induced the acute lung injury.ConclusionBML-111 protects haemorrhagic shock-induced acute lung injury in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Resuscitation - Volume 83, Issue 7, July 2012, Pages 907–912
نویسندگان
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