The state of systemic circulation, collapsed or preserved defines the need for hyperoxic or normoxic resuscitation in neonatal mice with hypoxia-ischemia

In murine HI associated with circulatory collapse the resuscitation limited to re-oxygenation with 100% O2 is superior to the use of RA in achievement of the ROSC. However, in HI-mice with preserved systemic circulation hyperoxic re-oxygenation has no benefit over the normoxic brain recovery.