کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3010456 1181515 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Post-cardiac arrest temperature manipulation alters early EEG bursting in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Post-cardiac arrest temperature manipulation alters early EEG bursting in rats
چکیده انگلیسی

SummaryObjectivesHypothermia improves outcomes after cardiac arrest (CA), while hyperthermia worsens injury. EEG recovers through periodic bursting from isoelectricity after CA, the duration of which is associated with outcome in normothermia. We quantified burst frequency to study the effect of temperature on early EEG recovery after CA.MethodsTwenty-four rats were divided into three groups, based on 6 h of hypothermia (T = 33 °C), normothermia (T = 37 °C), or hyperthermia (T = 39 °C) immediately post-resuscitation from 7-min asphyxial CA. Temperature was maintained using surface cooling and re-warming. Neurological recovery was defined by 72-h neurological deficit score (NDS).ResultsBurst frequency was higher during the first 90 min in rats treated with hypothermia (25.6 ± 12.2 min−1) and hyperthermia (22.6 ± 8.3 min−1) compared to normothermia (16.9 ± 8.5 min−1) (p < 0.001). Burst frequency correlated strongly with 72-h NDS in normothermic rats (p < 0.05) but not in hypothermic or hyperthermic rats. The 72-h NDS of the hypothermia group (74, 61–74; median, 25–75th percentile) was significantly higher than the normothermia (49, 47–61) and hyperthermia (43, 0–50) groups (p < 0.001).ConclusionsIn normothermic rats resuscitated from CA, early EEG burst frequency is strongly associated with neurological recovery. Increased bursting followed by earlier restitution of continuous EEG activity with hypothermia may represent enhanced recovery, while heightened metabolic rate and worsening secondary injury is likely in the hyperthermia group. These factors may confound use of early burst frequency for outcome prediction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Resuscitation - Volume 78, Issue 3, September 2008, Pages 367–373
نویسندگان
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