کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3010639 1181524 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts
چکیده انگلیسی

SummaryAimDexmedetomidine is a highly specific and selective α-2 adrenergic agonist that is now widely used in the intensive care setting. Many intensive care unit (ICU) patients are at risk of respiratory or cardiac arrest. This study was conducted to determine whether dexmedetomidine exhibits a cardioprotective effect on global ischaemia and subsequent myocardial infarction.MethodsIsolated rat hearts were subjected to 30 min of global ischaemia followed by 120 min reperfusion, with administration of 0, 1 and 10 nM dexmedetomidine during the pre-ischaemic period (n = 7 each group). Secondly, 1 μM yohimbine, an α-2 antagonist, was given during the pre-ischaemic period, alone or in combination with 10 nM dexmedetomidine (n = 7 each group).ResultsDexmedetomidine administration reduced coronary flow significantly (103.6 ± 4.7%, 77.9 ± 3.7, 63.7 ± 6.1%, of the baseline values for 0, 1 and 10 nM dexmedetomidine, respectively), and yohimbine administration reversed this effect (88.0 ± 2.2%). Dexmedetomidine improved the infarct size at each concentration (45.3 ± 3.6, 30.2 ± 3.3, and 21.2 ± 2.3% of the total left ventricular mass for 0, 1, and 10 nM dexmedetomidine, respectively), which was also reversed by yohimbine (43.6 ± 1.4%).ConclusionDexmedetomidine exhibited a cardioprotective effect on global ischaemia in the isolated rat heart model, which was mediated by α-2 adrenergic stimulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Resuscitation - Volume 74, Issue 3, September 2007, Pages 538–545
نویسندگان
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