کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3032049 1183995 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blood protein predictors of brain amyloid for enrichment in clinical trials?
ترجمه فارسی عنوان
پیشگیری از پروتئین خون آمیلوئید مغز برای غنی سازی در آزمایشات بالینی؟
کلمات کلیدی
پلاسما، β آمیلوئید، پروتئومیکس، بیماری آلزایمر، بیومارکر، فیبرینوژن γ زنجیره ای، آزمایشات بالینی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

BackgroundMeasures of neocortical amyloid burden (NAB) identify individuals who are at substantially greater risk of developing Alzheimer's disease (AD). Blood-based biomarkers predicting NAB would have great utility for the enrichment of AD clinical trials, including large-scale prevention trials.MethodsNontargeted proteomic discovery was applied to 78 subjects from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing with a range of NAB values. Technical and independent replications were performed by immunoassay.ResultsSeventeen discovery candidates were selected for technical replication. α2-Macroglobulin, fibrinogen γ-chain (FGG), and complement factor H-related protein 1 were confirmed to be associated with NAB. In an independent cohort, FGG plasma levels combined with age predicted NAB had a sensitivity of 59% and specificity of 78%.ConclusionA single blood protein, FGG, combined with age, was shown to relate to NAB and therefore could have potential for enrichment of clinical trial populations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - Volume 1, Issue 1, March 2015, Pages 48–60
نویسندگان
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