کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3036677 | 1184381 | 2015 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ketogenic diet therapy can improve ACTH-resistant West syndrome in Japan Ketogenic diet therapy can improve ACTH-resistant West syndrome in Japan](/preview/png/3036677.png)
Purpose: Ketogenic diet therapy (KD) has been used to treat children with refractory generalized epilepsy. We herein reported the efficacy of KD for West syndrome (WS) resistant to ACTH therapy. Subjects: Subjects, consisting of 6 patients (3 boys, 3 girls) with WS who continued to have epileptic spasms (ES) and hypsarrhythmia, received KD because other treatments including ACTH therapy failed to control WS. Methods: We retrospectively studied the clinical details of these patients and the efficacy of KD. Results: The mean age at the onset of epilepsy was 4 months (0–15 months). The underlying etiology consisted of lissencephaly, Down’s syndrome, and focal cortical dysplasia. Hypsarrhythmia disappeared 1 month after the introduction of KD in 5 patients. The disappearance of ES was achieved in 2 patients, the frequency of ES episodes was 80% less in 3, and no change was observed in 1. Psychomotor development was promoted in 5 patients, along with improvements in ES and EEG. Gastrointestinal complications and lethargy, presumably caused by rapid ketosis, were reported as side effects in 3 patients during the first week of KD. Side effects including lethargy, anorexia, and unfavorable weight gain continued thereafter in these patients in spite of tolerance to KD. Conclusion: KD was effective for WS resistant to ACTH therapy, although gastrointestinal side effects should be considered when introducing KD to milk-fed infants.
Journal: Brain and Development - Volume 37, Issue 1, January 2015, Pages 18–22