کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3036678 1184381 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy and tolerability of high-dose prednisone in Chinese children with infantile spasms
ترجمه فارسی عنوان
اثربخشی و تحمل دوز پردنیزون بالا در کودکان چینی با اسپاسم نوزادان
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

Objectives: The aim of this study is to preliminarily evaluate the clinical efficacy and safety of high-dose prednisone in the treatment of infantile spasms (IS) in China, and to provide additional choice of the therapy of IS. Methods: Twenty patients aged 3–53 months with IS were collected in the Department of Neurology of Jiangxi Children’s Hospital from May in 2011 to December in 2012, who were placed on high-dose prednisone (took prednisone tablet of 10 mg four times a day) for 2 weeks during admission to our hospital. The assessment of spasms seizure and video-EEG monitoring were preformed before treatment and after 2 weeks and the end of treatment of the regimen (7 weeks), respectively. All of the children were followed-up for 2–14 months. Results: Among 20 cases, there were 16 cases (80.0%) with complete cessation of spasms after 2 weeks and 13 cases (65.0%) after 7 weeks. There were 19 cases with typical or modified hypsarrhythmia in 20 cases. No matter after 2 or 7 weeks, there were 12 cases showed complete resolution of hypsarrhythmia and 7 cases with only a partial remission of hypsarrhythmia. After a follow-up of 2–14 months, the longest spasm-free interval was 14 months and the shortest one was 11 days. Six cases relapsed in different periods, and the relapse rate was 35.3%. Amongst the main adverse events, there were Cushing’s symptoms in 15 cases (75.0%), irritability in 8 cases (40.0%), drosiness in 3 cases (15.0%), high blood pressure in 3 cases (15.0%), and infections in 8 cases (40.0%), but no one stopped the treatment because of the adverse reactions. Conclusion: In total, high-dose prednisone was effective and well-tolerated in children with IS in China. Maybe the regimen will become a new choice in the treatment of IS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 37, Issue 1, January 2015, Pages 23–28
نویسندگان
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