کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3036802 | 1184385 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic factors for acute encephalopathy with bright tree appearance
ترجمه فارسی عنوان
عوامل پیش آگهی آنسفالوپاتی حاد با ظاهر درخت روشن
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کلمات کلیدی
آنسفالوپاتی حاد، آنسفالوپاتی حاد با تشنج دو طرفه و انتشار دیر کاهش یافته است. ظاهر درخت روشن، عوامل پیش آگهی، کراتینین، طیف سنجی رزونانس مغناطیسی، اوج لاکتات،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
چکیده انگلیسی
Objective: To determine the prognostic factors for encephalopathy with bright tree appearance (BTA) in the acute phase through retrospective case evaluation. Methods: We recruited 10 children with encephalopathy who presented with BTA and classified them into 2 groups. Six patients with evident regression and severe psychomotor developmental delay after encephalopathy were included in the severe group, while the remaining 4 patients with mild mental retardation were included in the mild group. We retrospectively analyzed their clinical symptoms, laboratory data, and magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) findings. Results: Patients in the severe group developed subsequent complications such as epilepsy and severe motor impairment. Univariate analysis revealed that higher maximum lactate dehydrogenase (LDH) levels (p = 0.055) were a weak predictor of poor outcome. Maximum creatinine levels were significantly higher (p < 0.05) and minimal platelet counts were significantly lower (p < 0.05) in the severe group than in the mild group. Acute renal failure was not observed in any patient throughout the study. MRS of the BTA lesion during the BTA period showed elevated lactate levels in 5 children in the severe group and 1 child in the mild group. MRI performed during the chronic phase revealed severe brain atrophy in all patients in the severe group. Conclusions: Higher creatinine and LDH levels and lower platelet counts in the acute phase correlated with poor prognosis. Increased lactate levels in the BTA lesion during the BTA period on MRS may predict severe physical and mental disability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 37, Issue 2, February 2015, Pages 191-199
Journal: Brain and Development - Volume 37, Issue 2, February 2015, Pages 191-199
نویسندگان
Junji Azuma, Shin Nabatame, Sayaka Nakano, Yoshiko Iwatani, Yukihiro Kitai, Koji Tominaga, Kuriko Kagitani-Shimono, Takeshi Okinaga, Takehisa Yamamoto, Toshisaburo Nagai, Keiichi Ozono,