کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3037649 1184424 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
αB-Crystallin negative astrocytic inclusions
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
αB-Crystallin negative astrocytic inclusions
چکیده انگلیسی

We report on an unusual pathological finding of astrocytes, observed in the brain of a 16-year-old African–American male with severe intellectual disability and spastic quadriplegia. The brain showed bilateral pericentral, perisylvian polymicrogyria and pachygyria, in conjunction with a large number of hypertrophic astrocytes with eosinophilic granular cytoplasmic inclusions. The astrocytic abnormality was more severe in the dysgenetic area but present throughout the cerebral cortex. Astrocytic inclusions stained with acid fuchsin, azocarmine and Holzer’s stain, and were immunoreactive for GFAP, S-100, and ubiquitin, but not for αB-crystallin, filamin, vimentin, nestin, tau or α-synuclein. Based on the case and a review of the literature, the authors postulate that these astrocytic inclusions in the cerebral cortex reflect abnormalities in radial glial developmental processes, such as migration, differentiation, or glial–neuronal interaction function during neuronal migration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 33, Issue 4, April 2011, Pages 349–352
نویسندگان
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