کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3037818 | 1184432 | 2010 | 8 صفحه PDF | دانلود رایگان |
ObjectivesBrain damage following a perinatal hypoxic–ischemic (HI) insult has been documented by different diagnostic techniques. The aim of the present study was to relate a-EEG time course during the first 24 h of life to brain metabolic changes detected by proton MR spectroscopy (1H-MRS) at 7–10 days of life and to evaluate their correlation with outcome.MethodsThirty-two patients with any grade HI encephalopathy were studied. Thirty-one out of 32 patients survived and underwent 1H-MRS examination at 7–10 days of life; a-EEG was recorded during the first 24 h of life in 27/32 newborns; 26 patients underwent both examinations. Griffiths test, evaluation of motor skills, visual and hearing function were performed at regular intervals until the age of 2 years.Resultsa-EEG at 6, 12 and 24 h of life showed a significant correlation with outcome. N-acetyl-aspartate/creatine (Cr), Lactate/Cr and myo-inositol differed significantly between patients with normal or poor outcome. a-EEG time course during the first 24 h of life showed improvement in newborns with normal 1H-MRS and good outcome and a deterioration in those with abnormal 1H-MRS and poor outcome.Conclusionsa-EEG time course may be able to document the severity and the evolution of the cerebral damage following an HI event. a-EEG is related to the severity of cerebral injury as defined by 1H-MRS and both examinations showed a good correlation with outcome. These data, obtained in non-cooled infants, may represent reference data for future investigations in cooled infants.
Journal: Brain and Development - Volume 32, Issue 10, November 2010, Pages 835–842