کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3038077 | 1184445 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tumor-like enlargement of the optic chiasm in an infant with Alexander disease
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tumor-like enlargement of the optic chiasm in an infant with Alexander disease Tumor-like enlargement of the optic chiasm in an infant with Alexander disease](/preview/png/3038077.png)
چکیده انگلیسی
We report a patient with infantile Alexander disease (AXD) due to the recurrent p.Arg79Cys GFAP mutation. In addition to typical AXD abnormalities, magnetic resonance imaging demonstrated a tumor-like lesion of the optic chiasm suggestive of a glioma. A transient papilloedema appeared during the follow-up and the lesion partially regressed despite a worsening of white matter involvement. Rare radiological and pathological tumor-like lesions have already been reported in AXD patients. This patient confirms that enlargement of the optic chiasm is a rare feature of AXD, possibly linked to abnormal astrocytic proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 31, Issue 3, March 2009, Pages 244-247
Journal: Brain and Development - Volume 31, Issue 3, March 2009, Pages 244-247
نویسندگان
Cyril Mignot, Isabelle Desguerre, Lydie Burglen, Lucie Hertz-Pannier, Florence Renaldo, Jean-François Gadisseux, Serge Gallet, Danielle Pham-Dinh, Odile Boespflug-Tanguy, Diana Rodriguez,