کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3038666 1184487 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Administration of secretin for autism alters dopamine metabolism in the central nervous system
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Administration of secretin for autism alters dopamine metabolism in the central nervous system
چکیده انگلیسی

We evaluated the clinical effects of intravenously administered secretin in 12 children with autism (age range: 4–6 years, median age: 9 years, boy:girl=8:4). In addition, we investigated the association between improvement in symptoms and changes in the cerebrospinal fluid (CSF) homovanillic acid (HVA),5-hydroxyindole-3-acetic acid (5-HIAA), and 6R-5,6,7,8-tetrahydro-L-biopterin (BH4) levels after administration. After administration of secretin, the Autism Diagnostic Interview-Revised (ADI-R) score improved in 7 of the 12 children. However, the score deteriorated in 2 of the 12 children (in the item of ‘restricted and repetitive, stereotyped interests and behaviors’). The HVA and BH4 levels in CSF were increased in all children with improvement in the ADI-R score. In contrast, no patient without the elevation of the BH4 level showed improvement in the score. These findings suggest that secretin activated metabolic turnover of dopamine in the central nervous system via BH4, improving symptoms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 28, Issue 2, March 2006, Pages 99–103
نویسندگان
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