Methods for Specific Electrode Resistance Measurement During Transcranial Direct Current Stimulation

• First approach to monitor individual electrode resistance during tDCS.
• Methodologies using a low intensity and frequency sinusoids and a sentinel tested.
• A test signal can predict DC electrode resistance based on our methodologies.
• Possible errors in resistance measurement tested through our invention.

BackgroundMonitoring of electrode resistance during tDCS is considered important for tolerability and safety. Conventional resistance measurement methods do not isolate individual electrode resistance and for HD-tDCS devices, cross talk across electrodes makes concurrent resistance monitoring unreliable.ObjectiveWe propose a novel method to monitor individual electrode resistance during tDCS, using a super-position of direct current with a test-signal (low intensity and low frequency sinusoids with electrode–specific frequencies) and a sentinel electrode (not used for DC).MethodsWe developed and solved lumped-parameter models of tDCS electrodes with or without a sentinel electrode to validate this methodology. Assumptions were tested and parameterized in participants using forearm stimulation combining tDCS (2 mA) and test-signals (38 and 76 μA pk-pk at 1 Hz, 10 Hz, & 100 Hz) and an in vitro test (creating electrode failure modes). DC and AC component voltages across the electrodes were compared and participants were asked to rate subjective pain.ResultsA sentinel electrode is required to isolate electrode resistance in a two-electrode tDCS system. Cross talk aggravated with electrode proximity and resistance mismatch in multi-electrode resistance tracking could be corrected using proposed approaches. Average voltage and pain scores were not significantly different across test current intensities and frequencies.ConclusionUsing our developed method, a test signal can predict DC electrode resistance. Since unique test frequencies can be used at each tDCS electrode, specific electrode resistance can be resolved for any number of stimulating channels - a process made still more robust by the use of a sentinel electrode.