moviEEG: An animation toolbox for visualization of intracranial electroencephalography synchronization dynamics

• We present an open source MATLAB-based toolbox for spatiotemporal mapping of network synchronization dynamics in intracranial electroencephalography data.
• Connectivity dynamics including seizure network coalescence and fractioning are visualized and overlaid over operating room images of the electrode grid.
• Two case studies provide preliminary evidence for application of the toolbox in mapping epileptogenic cortex.

ObjectiveWe introduce and describe the functions of moviEEG (Multiple Overlay Visualizations for Intracranial ElectroEncephaloGraphy), a novel MATLAB-based toolbox for spatiotemporal mapping of network synchronization dynamics in intracranial electroencephalography (iEEG) data.MethodsThe toolbox integrates visualizations of inter-electrode phase-locking relationships in peri-ictal epileptogenic networks with signal spectral properties and graph-theoretical network measures overlaid upon operating room images of the electrode grid. Functional connectivity between every electrode pair is evaluated over a sliding window indexed by phase synchrony.ResultsTwo case studies are presented to provide preliminary evidence for the application of the toolbox to guide network-based mapping of epileptogenic cortex and to distinguish these regions from eloquent brain networks. In both cases, epileptogenic cortex was visually distinct.ConclusionWe introduce moviEEG, a novel toolbox for animation of oscillatory network dynamics in iEEG data, and provide two case studies showing preliminary evidence for utility of the toolbox in delineating the epileptogenic zone.SignificanceDespite evidence that atypical network synchronization has shown to be altered in epileptogenic brain regions, network based techniques have yet to be incorporated into clinical pre-surgical mapping. moviEEG provides a set of functions to enable easy visualization with network based techniques.