کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
3042893 1184966 2016 10 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index
ترجمه فارسی عنوان
منابع غيرطبيعي قشری از ريتم‌هاي الکتروانسفالوگرافي وضعيت استراحت در افراد مبتلا به HIV بدون درمان مؤثر: يک شاخص آماري نمره z
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کلمات کلیدی
ویروس نقص ایمنی بدن (HIV)؛ الکتروانسفالوگرافی حالت حالت (EEG)؛ توموگرافی منبع الکترومغناطیسی مغز کوچک (LORETA)؛ نمره Z؛ تراکم قدرت دلتا / آلفا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• This pilot study tested a statistical z-score procedure to identify single treatment-naïve HIV individuals having abnormal resting state electroencephalographic (EEG) sources.
• Compared to HIV individuals with normal EEG sources, those (47.6%) with abnormal z-score values showed worse cognitive and serological markers.
• This procedure is promising to assess effects of HIV on brain function in single treatment-naïve HIV individuals.

ObjectiveThis study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (<4 Hz) and alpha (8–13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status.MethodsResting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys. ± 1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys. ± 2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.ResultsRatio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p < 0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p < 0.05).ConclusionsThis statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.SignificanceThis procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 3, March 2016, Pages 1803–1812
نویسندگان
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