کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3043065 1184969 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiology of functional and effective networks in epilepsy
ترجمه فارسی عنوان
فیزیولوژی شبکه های کاربردی و موثر در صرع
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• The relationships between functional and structural networks provide insights into brain abnormalities that are observed in epilepsy.
• Functional and effective connectivity methods have been used to identify the ictal onset zone as well as to characterize the onset, spread, and termination of seizures.
• Studies of the dynamics of epileptic networks suggest mechanisms that may explain the sudden onset and termination of seizures.

Epilepsy is a network phenomenon characterized by atypical activity during seizure both at the level of single neurons and neural populations. The etiology of epilepsy is not completely understood but a common theme among proposed mechanisms is abnormal synchronization between neuronal populations. Recent advances in novel imaging and recording technologies have enabled the inference of comprehensive maps of both the anatomical and physiological inter-relationships between brain regions. Clinical protocols established for diagnosis and treatment of epilepsy utilize both advanced neuroimaging techniques and neurophysiological data. These growing clinical datasets can be further exploited to better understand the complex connectivity patterns in the epileptic brain. In this article, we review results and insights gained from the growing body of research focused on epilepsy from a network perspective. In particular, we put an emphasis on two different notions of network connectivity: functional and effective; and studies investigating these notions in epilepsy are highlighted. We also discuss limitations and opportunities in data collection and analyses that will further our understanding of epileptic networks and the mechanisms of seizures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 126, Issue 2, February 2015, Pages 227–236
نویسندگان
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