کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3043138 1184972 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dissociation of anatomical and functional alterations of the default-mode network in first-episode, drug-naive schizophrenia
ترجمه فارسی عنوان
جداسازی تغییرات تشریحی و عملکردی شبکه پیش فرض حالت در بخش اول، اسکیزوفرنی ناشی از مواد مخدر
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• A dissociation pattern indicated that brain functional and anatomical abnormalities of the default-mode network (DMN) might be present independently in schizophrenia.
• The recruitment of first-episode, drug-naive schizophrenia patients offers insight into the pathophysiology of schizophrenia independently of treatment issues.
• Functional and structural abnormalities highlight the importance of DMN in the pathophysiology of schizophrenia.

ObjectiveAnatomical and functional alterations of the default-mode network (DMN) have been implicated in the pathophysiology of schizophrenia. However, no study is engaged to explore whether structural and functional abnormalities of the DMN overlap in schizophrenia. This study was undertaken to examine whether anatomical and functional abnormalities are present in similar or different brain regions of the DMN in first-episode, drug-naive schizophrenia.MethodsForty-nine first-episode, drug-naive schizophrenia patients and 50 age-, sex-, and education-matched healthy controls underwent structural and resting-state functional magnetic resonance imaging (fMRI) scanning. The voxel-based morphometry (VBM) and fractional amplitude of low-frequency fluctuation (fALFF) methods were used to analyze imaging data.ResultsThe patients exhibited significantly decreased gray matter volume (GMV) in the left medial prefrontal cortex (orbital part) and increased fALFF in the left posterior cingulate cortex compared with the controls. No overlap of brain regions with anatomical and functional abnormalities was observed in the patient group. There was also no correlation between decreased GMV/increased fALFF and clinical variables in patients.ConclusionsA dissociation pattern of brain regions with anatomical and functional changes within the DMN is revealed in schizophrenia patients.SignificanceOur findings suggest that brain functional and anatomical abnormalities within the DMN might contribute independently to the pathophysiology of schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 126, Issue 12, December 2015, Pages 2276–2281
نویسندگان
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