کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3043804 1184985 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spinal associative stimulation: A non-invasive stimulation paradigm to modulate spinal excitability
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Spinal associative stimulation: A non-invasive stimulation paradigm to modulate spinal excitability
چکیده انگلیسی

ObjectiveRepetitive, paired peripheral and transcranial stimulation targeting the cerebral cortex can increase cortical excitability, outlasting the stimulation period. It is unknown whether paired stimulation specifically targeting the spinal cord can modulate spinal excitability. We tested whether the H-reflex facilitation from a sub-threshold conditioning TMS pulse could modulate spinal excitability if delivered repetitively.MethodIn 13 healthy subjects, we delivered single-pulse TMS (80% RMT) for the right soleus muscle, 20 ms prior to an electrical peripheral nerve stimulus delivered over the posterior tibial nerve on the same side at 0.1 Hz during 15 min.ResultsPNS alone evoked an H-reflex of 0.25 mV ± 0.06 SEM, while pairing of TMS and PNS facilitated the H-reflex to 0.7 ± 0.11 mV. TMS–PNS pairs delivered at 0.1 Hz for 15 min progressively increased in the evoked response to ∼130% (r2 = 0.97) of the starting amplitude (normalized to 1st min). Post-intervention, H-reflex threshold decreased (pre = 12.9 ± 1.7 mA; post = 11.6 ± 1.6 mA; p = 0.04), as did the stimulus intensity at maximum H-reflex amplitude (pre = 23.5 ± 02.8 mA; post = 21.6 ± 2.6 mA; p = 0.03), and recruitment curve width (pre = 11.6 ± 1.5 mA; post = 10.93 ± 1.4 mA; p = 0.03). No such changes were observed with intervention of PNS or TMS alone.ConclusionPaired stimulation targeting spinal facilitatory interactions, when applied repetitively, can increase spinal excitability during and after the intervention.SignificanceSpinal associative stimulation may have potential for neuromodulation in spinal cord injury patients.


► Induction of spinal cord plasticity associated with central and peripheral interactions.
► Repetitive paired intervention (SAS) induces changes in H-reflex recruitment curve.
► Spinal associative stimulation can effectively modulate spinal cord excitability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 122, Issue 11, November 2011, Pages 2254–2259
نویسندگان
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