کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3043947 1184989 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in Parkinson’s disease
ترجمه فارسی عنوان
الگوهای غیر طبیعی نوسانات فرکانس تتا در طول تحول تاریخی یخ زدگی راه رفتن در بیماری پارکینسون
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• Electrophysiology can offer novel insights into the spatiotemporal dynamics underlying episodes of freezing of gait.
• Episodes of freezing of gait display a unique signature of abnormal oscillatory activity in theta band power spectral density.
• The results provide a potential means for therapeutic prediction and alleviation of freezing episodes in susceptible patients.

ObjectiveWe sought to characterize the electrophysiological signature of Freezing of gait in Parkinson’s disease.MethodsWe examined 24 patients with idiopathic Parkinson’s disease and significant freezing of gait as they performed a series of timed up-and-go tasks in their ‘off’ state while electroencephalographic data was collected from four scalp leads. Fast Fourier Transformation was utilized to explore the power spectral density between periods of normal walking and periods of freezing, as well as during the transition between the two states. In addition, Cross Spectrum and Cross Frequency analyses were used to explore the role of impaired temporal and spatial connectivity.ResultsWhen compared to walking, episodes of freezing were associated with a significant increase in theta band power within the central and frontal leads. The transition from normal walking to freezing of gait was also associated with increased theta frequency coupling between the central and frontal leads, along with an increase in cross-frequency coupling in the central lead.ConclusionsEpisodes of freezing of gait in Parkinson’s disease are associated with abnormal oscillatory activity in the brain.SignificanceThese results provide novel insights into the pattern of spatiotemporal dynamics underlying freezing of gait and may provide a potential means for therapeutic prediction and alleviation of freezing episodes in susceptible patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 125, Issue 3, March 2014, Pages 569–576
نویسندگان
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