کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3044240 1184995 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impaired neuronal synchrony after focal ischemic stroke in elderly patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Impaired neuronal synchrony after focal ischemic stroke in elderly patients
چکیده انگلیسی

ObjectiveThis study investigated whether cortical synchrony derived from electroencephalography (EEG) in elderly patients is impaired and if the impairment might reflect long-term functional recovery after stroke.MethodsThe scalp EEG signals of stroke patients (N = 42) were collected within seven days after the onset of stroke and analyzed with phase synchronization (PS). Neurodeficit outcome was scored twice according to the National Institute of Health Stroke Scale (NIHSS): (1) at the same day of EEG recording and (2) two months after stroke. The correlation between cortical synchrony and NIHSS was analyzed.ResultsThe level of synchronization between lesion and intact areas in the ipsilateral hemisphere was reduced significantly after stroke, while the synchronization among intact areas increased to 114% among the control subjects. Furthermore, the patients with lower inter-hemispheric synchrony after stroke were observed to have a higher NIHSS two months after stroke.ConclusionsResults indicated that the infarct broke down the cortical synchrony networks and affected large-scale neural communication. Inter-hemispheric synchrony was relevant to long-term functional recovery after stroke.SignificanceThe prognostic value of PS for functional recovery after stroke might be helpful in understanding the alteration of cortical networks after ischemic injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 122, Issue 1, January 2011, Pages 21–26
نویسندگان
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