کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3044483 1185001 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantifying muscle asymmetries in cervical dystonia with electrical impedance: A preliminary assessment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Quantifying muscle asymmetries in cervical dystonia with electrical impedance: A preliminary assessment
چکیده انگلیسی

ObjectiveCervical dystonia (CD) lacks an objective quantitative measure. Electrical impedance myography (EIM) is a non-invasive assessment method sensitive to changes in muscle structure and physiology. We evaluate the potential role of EIM in quantifying CD, hypothesizing that patients would demonstrate differences in the symmetry of muscle electrical resistance compared to controls, and that this asymmetry would decrease after botulinum neurotoxin (BoNT) treatment.MethodsEIM was performed on the sternocleidomastoid (SCM) and cervical paraspinal (PS) muscles of CD patients and age-matched controls. 50 kHz resistance was analyzed, comparing side-to-side asymmetry in patients and controls, and, in patients, before and after BoNT treatment.ResultsSixteen patients and 10 controls were included. Resistance asymmetry was on average 3–5 times higher in patients than controls. Receiver operating characteristic analysis demonstrated 91% accuracy of discriminating CD from normal. From pre-treatment to maximum BoNT effect, asymmetry decreased from 20.8(13.9–26.1)% to 6.2(3.1–9.9)% (SCM), and from 16.0(14.3–16.0)% to 8.4(7.0–9.2)% (PS), p < 0.05 (median, interquartile range).ConclusionsEIM effectively differentiates normal subjects from CD patients by revealing asymmetries in resistance values and detects improvement in muscle symmetry after treatment.SignificanceThese results suggest that EIM, a painless, non-invasive measure, can provide a useful quantitative metric in CD evaluation and deserves further study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 122, Issue 5, May 2011, Pages 1027–1031
نویسندگان
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