کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3044843 1185010 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased spike frequency during general anesthesia with etomidate for magnetoencephalography in patients with focal epilepsies
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Increased spike frequency during general anesthesia with etomidate for magnetoencephalography in patients with focal epilepsies
چکیده انگلیسی

ObjectiveMagnetoencephalography (MEG) is used for focus localization in presurgical evaluation of patients with focal epilepsies. In this proof-of-concept study, general anesthesia with etomidate was used to improve effectiveness of MEG-recordings.MethodsMEG-recordings of six patients with focal epilepsy were performed before and after application of etomidate. Spike frequency and localization accuracy of MEG with general anesthesia were compared with spontaneous MEG.ResultsAfter application of etomidate, an increase in spike frequency occurred in all patients, and movement artifacts were prevented. In one patient, spikes could only be detected by invasive EEG but not by MEG. The results were in accordance with spontaneous MEG or presurgical hypotheses about localizations of neocortical foci in three patients. Dipole localizations were distributed over fronto-temporal areas in three patients with ipsilateral temporo-mesial focus hypotheses.ConclusionsEtomidate ameliorated spike yield and stopped movement artifacts during MEG recordings in patients with focal epilepsy. Localization results were especially accurate in patients with neocortical epilepsy.SignificanceThese results could facilitate larger studies on the usefulness and safety of general anesthesia with etomidate that record and localize epileptic activity in patients with focal epilepsy by MEG.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 121, Issue 8, August 2010, Pages 1220–1226
نویسندگان
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