Source localization of interictal spike-locked neuromagnetic oscillations in pediatric neocortical epilepsy

ObjectiveTo evaluate the utility of an event-related beamforming (ERB) algorithm in source localization of interictal discharges.MethodsWe analyzed interictal magnetoencephalography data in 35 children with intractable neocortical epilepsy. We used a spatiotemporal beamforming method to estimate the spatial distribution of source power in individual interictal spikes. We compared ERB results to source localization using the equivalent current dipole model and to the seizure onset zones on intracranial EEG.ResultsFocal beamformer localization was observed in 66% of patients and multifocal in the remaining 34%. ERB localized within 2 cm of the equivalent current dipole cluster centroid in 77% of the patients. ERB localization was concordant with the seizure onset zone on intracranial EEG at the gyral level in 69% of patients. Focal ERB localization area was included in the resection margin in 22/23 patients. However, focal ERB localization was not statistically associated with better surgical outcome.ConclusionsERB can be used for source localization of interictal spikes and can be predictive of the ictal onset zone in a subset of patients with neocortical epilepsy.SignificanceThese results support the utility of beamformer source localization as a fast semi-automated method for source localization of interictal spikes and planning the surgical strategy.

► Beamformer localization of interictal spikes corresponds to the centroid of MEG spike sources cluster.
► Event-related beamformer localization is concordant with the seizure onset zone on intracranial EEG at the gyral level in 69% of patients.
► In subset of patients with focal event-related beamformer localization, beamformer results were concordant with the ictal onset zone on intracranial EEG in 22/23 patients.