کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3046911 1185050 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural generators of brain potentials before rapid eye movements during human REM sleep: A study using sLORETA
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Neural generators of brain potentials before rapid eye movements during human REM sleep: A study using sLORETA
چکیده انگلیسی

ObjectiveBrain activity preceding rapid eye movements (REM) during human REM sleep has remained poorly understood. Slow negative brain potential (pre-REM negativity) appears before REMs. Current sources of this potential were investigated to identify brain activity immediately preceding REMs.MethodsIn this study, 22 young healthy volunteers (20–25 years old) participated. Polysomnograms were recorded during normal nocturnal sleep. Brain potentials between 200 ms before and 50 ms after the onset of REMs and pseudo-triggers (3000 ms before the onset of REMs) were averaged. Standardized low-resolution brain electromagnetic tomography (sLORETA) was used to estimate current sources of pre-REM negativity.ResultsPre-REM negativity appeared with the maximal amplitude at right prefrontal sites immediately before REMs. However, this negativity did not appear before pseudo-triggers. Current sources of the pre-REM negativity were estimated in the ventromedial prefrontal cortex, uncus, insula, anterior cingulated cortex, basal forebrain, parahippocampal gyrus, premotor cortex and frontal eye field.ConclusionsThe pre-REM negativity reflects brain activity coupled with the occurrence of REMs. Results of this study suggest that emotion, memory, and motor-related brain activity might occur before REMs.SignificancePre-REM negativity is expected to be a psychophysiological index for elucidating functions of REM sleep.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 119, Issue 9, September 2008, Pages 2044–2053
نویسندگان
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