کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3052000 1579912 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced cortical activation in inferior frontal junction in Unverricht–Lundborg disease (EPM1) – A motor fMRI study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Reduced cortical activation in inferior frontal junction in Unverricht–Lundborg disease (EPM1) – A motor fMRI study
چکیده انگلیسی


• Fifteen EPM1-patients and 15 matched controls underwent motor functional MRI.
• Decreased activation on left inferior frontal junction when compared with controls.
• Patients had weaker activation on the hand knob and SMA than controls.
• Higher T-value parameters in SMA were associated with shorter disease durations.

SummaryBackgroundUnverricht–Lundborg disease (EPM1) is characterized by stimulus-sensitive and action-activated myoclonus, tonic–clonic seizures and ataxia. Several disease-related alterations in cortical structure and excitability have been associated with the motor symptoms of EPM1. This study aimed to elucidate possible alterations in cortical activation related to motor performance in EPM1.MethodsFifteen EPM1-patients and 15 healthy volunteers matched for age and sex underwent motor functional MRI. Group differences in activations were evaluated in the primary and supplementary motor cortices and sensory cortical areas. Furthermore, in EPM1 patients, the quantitative fMRI parameters were correlated with the severity of the motor symptoms.ResultsThe EPM1-patients exhibited decreased activation in the left inferior frontal junction (IFJ) during right hand voluntary motor task when compared with controls. In the quantitative analysis, EPM1-patients had significantly weaker activation than controls in the hand knob and supplementary motor areas (SMA). The volume of activation in M1 decreased with age and duration of disease in the patient group, whereas the volume increased with age in controls. Negative correlations were observed between fMRI parameters of SMA and disease duration or age in patients but not in controls.ConclusionsThe weaker motor fMRI activation observed in EPM1 patients parallels previous neurophysiological findings and correlates with the motor symptoms of the disease. Thus, the observed decrease in IFJ activation in EPM1 patients may be associated with the difficulties in initiation or termination of motor execution, a typical clinical symptom in EPM1. The fMRI findings reflect the progressive nature of this disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 111, March 2015, Pages 78–84
نویسندگان
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