کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3052056 | 1186076 | 2014 | 8 صفحه PDF | دانلود رایگان |
• We characterized the EEG features of familial spontaneous epileptic cats (FSECs).
• Scalp EEGs in FSECs show interictal discharges in uni or bilateral temporal regions.
• Bemegride activations reveal that FSECs have a predisposition of epileptogenicity.
• Video-EEGs demonstrate that focal seizures arise from the amygdala or hippocampus.
• FSECs are a valuable animal model of human temporal lobe epilepsy.
SummaryA feline strain of familial spontaneous epileptic cats (FSECs) with typical limbic seizures was identified in 2010, and have been maintained as a novel animal model of genetic epilepsy. In this study, we characterized the electroencephalographic (EEG) features of FSECs. On scalp EEG under sedation, FSECs showed sporadic, but comparatively frequent interictal discharges dominantly in the uni- or bilateral temporal region. Bemegride activation was performed in order to evaluate the predisposition of epileptogenicity of FSECs. The threshold doses of the first paroxysmal discharge, clinical myoclonus and generalized convulsion in FSECs were significantly lower than those in control cats. Chronic video-intracranial EEG monitoring revealed subclinical or clinical focal seizures with secondarily generalization onset from the unilateral amygdala and/or hippocampus. Clinical generalized seizures were also recorded, but we were unable to detect the onset site. The results of the present study show that FSECs resemble not only feline kindling or the kainic acid model and El mouse, but also human familial or sporadic mesial temporal lobe epilepsy. In addition, our results indicate that FSECs are a natural and valuable model of mesial temporal lobe epilepsy.
Journal: Epilepsy Research - Volume 108, Issue 6, August 2014, Pages 1018–1025