کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3052195 | 1579921 | 2012 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Correlations between ictal propagation and response to electrical cortical stimulation: A cortico-cortical evoked potential study Correlations between ictal propagation and response to electrical cortical stimulation: A cortico-cortical evoked potential study](/preview/png/3052195.png)
SummaryObjectiveTo better understand the process of ictal propagation in epilepsy by using cortico-cortical evoked potential (CCEP), which reveals the brain networks.MethodsIntracranial EEG recordings of 11 seizures from 11 patients with pharmacoresistant focal epilepsy were studied to identify the propagation sites and times. Six patients had a history of secondary generalization (Gen (+) group) and five patients did not (Gen (−) group). Thereafter repetitive 1 Hz bipolar electrical stimuli were applied to the ictal onset zones and CCEPs were recorded by averaging electrocorticograms.ResultsThe propagation of contiguous spread was significantly faster than non-contiguous spread (p = 0.033). In four patients, CCEP amplitudes were significantly larger in the ictal propagation area than out of the propagation area. However, the distribution of CCEP responses was not necessarily consistent with the ictal propagation area as a whole. Furthermore, the ictal propagation areas out of CCEP-positive areas were significantly broader in Gen (+) group than Gen (−) group (p = 0.017).ConclusionThe present findings suggest that contiguous spread is faster than non-contiguous spread, which can be explained by the enhancement of excitability around the ictal onset area. Furthermore, there is a group of fibers that is “closed” during the seizures and secondary generalization might be more associated with the impairment of cortical inhibition over the broad cortical area rather than direct connection.
Journal: Epilepsy Research - Volume 101, Issues 1–2, August 2012, Pages 76–87