Intramuscular and intravenous levetiracetam in humans: Safety and pharmacokinetics

SummaryA study in dogs demonstrated that the commercially available formulation of IV levetiracetam (LEV) could be given safely IM and was quickly and completely absorbed. In this crossover study, 5 women and 5 men were given IM and IV LEV. This study demonstrates that administration of 5 ml (500 mg) IM LEV is well tolerated and its bioavailability is equivalent to an IV injection.