کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3052630 | 1579935 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model](/preview/png/3052630.png)
SummaryGanaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABAA receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25–20 mg/kg, s.c.) causes a dose-dependent suppression of behavioral and electrographic seizures in fully amygdala-kindled female mice, with nearly complete seizure protection at the highest dose tested. The ED50 for suppression of behavioral seizures was 6.6 mg/kg. The seizure suppression produced by ganaxolone was comparable to that of clonazepam (ED50, 0.1 mg/kg, s.c.). To the extent that amygdala kindling represents a model of mesial temporal lobe epilepsy, this study supports the utility of ganaxolone in the treatment of patients with temporal lobe seizures.
Journal: Epilepsy Research - Volume 89, Issues 2–3, May 2010, Pages 254–260