کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3052751 1579938 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment of Rasmussen encephalitis half a century after its initial description: Promising prospects and a dilemma
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Treatment of Rasmussen encephalitis half a century after its initial description: Promising prospects and a dilemma
چکیده انگلیسی

SummaryRasmussen encephalitis (RE), initially described half a century ago, is an inflammatory unihemispheric brain disorder. Its two clinical key facets are the progressive tissue and function loss and the epilepsy, often in form of epilepsia partialis continua. For both, treatment options are available. Anti-seizure effect of anti-epilepsy drugs is usually limited to secondarily generalized seizures and complex partial seizures whereas epilepsia partialis continua usually is totally refractory. Hemispherectomy in one of its modern variants offers a very high chance of seizure freedom, however at the price of irreversible loss of functions located in the affected hemisphere. In a proportion of patients, long-term immunotherapy is able to prevent or slow down hemispheric tissue loss and the associated functional decline. It does, however, mostly not improve the epilepsy. Whereas for many patients unequivocal treatment proposals can be readily made, a dilemma may emerge in those with severe epilepsy but still preserved hemispheric function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 86, Issues 2–3, October 2009, Pages 101–112
نویسندگان
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