کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3053020 1186138 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons
چکیده انگلیسی

SummaryTo test the putative serotonin (5-HT)-like effect of zonisamide (ZNS) we employed xanthine-induced epileptiform activity in the hippocampus slice preparation from guinea pigs. In this model Na+- and T-type Ca2+ channel blockers are hardly effective while 5-HT should be inhibitory. Bath application of 5-HT hyperpolarized neurons and abolished theophylline-induced epileptiform activity. In contrast, ZNS failed to alter epileptiform bursting. We conclude that 5-HT augmenting effects of ZNS are missing or are not sufficient to inhibit epileptiform activity in hippocampal slice preparations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 76, Issue 1, August 2007, Pages 73–76
نویسندگان
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