کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3053050 1579949 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: Role for nitric oxide signaling pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: Role for nitric oxide signaling pathway
چکیده انگلیسی

SummaryMelatonin has different interactions with opioids including enhancing their analgesic effect and reversal of opioid tolerance and dependence. Opioids are known to exert dose-dependent anti- and proconvulsant effects in different experimental seizure paradigms. This study investigated the effect of melatonin on biphasic modulation of seizure susceptibility by morphine, in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures. We further investigated the involvement of the nitric oxidergic pathway in this interaction, using a nitric oxide synthase inhibitor, NG-nitro-l-arginine-methyl-ester (L-NAME). Melatonin exerted anticonvulsant effect with doses as high as 40–80 mg/kg, but with a dose far bellow that amount (10 mg/kg), it potentiated both the anticonvulsant and proconvulsant effects of morphine on the PTZ-induced clonic seizures. Possible pharmacokinetic interaction of melatonin and morphine cannot be ruled out in the enhancement of two opposing effects of morphine on seizure threshold. L-NAME (1 mg/kg) reversed the anticonvulsant property of the combination of melatonin (10 mg/kg) plus morphine (0.5 mg/kg). Moreover, L-NAME (5 mg/kg) blocked the enhancing effect of melatonin (10 mg/kg) on proconvulsant activity of morphine (60 mg/kg). Our results indicate that co-administration of melatonin enhances both anti- and proconvulsant effects of morphine via a mechanism that may involve the nitric oxidergic pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 75, Issues 2–3, July 2007, Pages 138–144
نویسندگان
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