کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3053227 | 1579951 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The evaluation of antimuscarinic-induced convulsions in fasted rats after food intake
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study was performed to evaluate convulsions after food intake in fasted rats pretreated with scopolamine or atropine and to determine whether these convulsions respond to drugs found effective in fasted mice. Scopolamine (2.4Â mg/kg) and atropine (2.4Â mg/kg) were given intraperitoneally (i.p.) to rats fasted for 52Â h. Both drugs induced convulsions after animals were allowed to eat ad lib. Another group of fasted rats pretreated with saline, MK-801 (0.1Â mg/kg), clonidine (0.1Â mg/kg), chlorpromazine (2 and 4Â mg/kg), valproate (200Â mg/kg), diazepam (1.5 and 2Â mg/kg) or gabapentin (50Â mg/kg) were treated i.p. with saline or scopolamine (2.4Â mg/kg) and were allowed to eat ad lib. Clonidine, MK-801, chlorpromazine (4Â mg/kg) and diazepam (2Â mg/kg) reduced the incidence of scopolamine-induced convulsions in fasted rats. Gabapentin could only prolong the onset of convulsions. Neither treatment was effective against myoclonus of hindlimbs. Present results showed that fasted rats also develop antimuscarinic-induced convulsions which do not completely respond to treatments found effective in convulsions of fasted mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 72, Issues 2â3, December 2006, Pages 171-177
Journal: Epilepsy Research - Volume 72, Issues 2â3, December 2006, Pages 171-177
نویسندگان
Asiye Nurten, Nurhan Enginar,