کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3053597 | 1580010 | 2015 | 7 صفحه PDF | دانلود رایگان |
• We examined 40 children to clarify the clinical and radiological spectrum of PRES.
• 29 patients had ADC map in the acute period and 13 had lower ADC.
• 26 patients with follow-up MRI, 13 had focal gliosis or cortical atrophy.
• No patients had motor impairment, and four patients had focal epilepsy.
• Low ADC in the acute period was prognostic for focal gliosis or atrophy.
ObjectiveTo clarify the clinical and radiological spectrum of posterior reversible encephalopathy syndrome (PRES) in children, and to identify the prognostic factors.MethodsThe records of 40 children with PRES were reviewed. Acute clinical symptoms, MRI including apparent diffusion coefficient (ADC) maps in the acute and follow-up periods and neurological sequelae, including epilepsy, were noted.ResultsAge at onset ranged from 2 to 16 years. Underlying disorders were hematological or neoplastic disorders (n = 20), renal diseases (n = 14) and others (n = 6). In the acute period, 31 patients had seizures, 25 had altered consciousness, 11 had visual disturbances and 10 had headache. Of 29 patients who had ADC maps in the acute period, 13 had reduced diffusivity as shown by ADC within PRES lesions. Of 26 patients with follow-up MRI, 13 had focal gliosis or cortical atrophy. No patients had motor impairment, and four patients had focal epilepsy. No clinical variables were associated with focal gliosis or cortical atrophy on follow-up MRI, but lesional ADC reduction in the acute period was prognostic for focal gliosis or cortical atrophy on follow-up MRI (p = 0.005).ConclusionsTo the best of our knowledge, this is the largest cohort study to date involving PRES in children. Acute symptoms in pediatric patients are similar to those reported in adults, but altered consciousness was more frequent in children. Lesional ADC reduction in the acute period was common and was a good predictor of later, irreversible MRI lesions.
Journal: European Journal of Paediatric Neurology - Volume 19, Issue 6, November 2015, Pages 672–678