کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3053631 1580011 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Language comprehension in nonspeaking children with severe cerebral palsy: Neuroanatomical substrate?
ترجمه فارسی عنوان
درک زبان در کودکان مبتلا به فلج مغزی شدید: بستر نوروآنتیومیک چیست؟
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


• Comprehension of spoken language differs between MRI patterns of severe CP.
• In our severely affected population, we found no relation between GM areas and spoken language comprehension.
• Damage to especially WM areas is associated with adverse effect on language comprehension outcomes.
• Language comprehension was most affected in children with WM lesions in the subcortical and then periventricular areas.

Background and aimsTo identify relations between brain abnormalities and spoken language comprehension, MRI characteristics of 80 nonspeaking children with severe CP were examined.MethodsMRI scans were analysed for patterns of brain abnormalities and scored for specific MRI measures: white matter (WM) areas; size of lateral ventricles, WM abnormality/reduction, cysts, subarachnoid space, corpus callosum thinning and grey matter (GM) areas; cortical GM abnormalities, thalamus, putamen, globus pallidus and nucleus caudatus and cerebellar abnormalities. Language comprehension was assessed with a new validated instrument (C-BiLLT).ResultsMRI scans of 35 children were classified as a basal ganglia necrosis (BGN) pattern, with damage to central GM areas; in 60% of these children damage to WM areas was also found. MRI scans of 13 children were classified as periventricular leukomalacia (PVL) with little concomitant damage to central GM areas, 13 as malformations and 19 as miscellaneous. Language comprehension was best in children with BGN, followed by malformations and miscellaneous, and was poorest in PVL. Linear regression modelling per pattern group (malformations excluded), with MRI measures as independent variables, revealed that corpus callosum thinning in BGN and parieto-occipital WM reduction in PVL were the most important explanatory factors for poor language comprehension. No MRI measures explained outcomes in language comprehension in the miscellaneous group.ConclusionsComprehension of spoken language differs between MRI patterns of severe CP. In children with BGN and PVL differences in language comprehension performance is attributed to damage in the WM areas. Language comprehension was most affected in children with WM lesions in the subcortical and then periventricular areas, most characteristic for children with PVL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 19, Issue 5, September 2015, Pages 510–520
نویسندگان
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