کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3054405 1580052 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy of pregabalin in neuropathic pain in paediatric oncological patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Efficacy of pregabalin in neuropathic pain in paediatric oncological patients
چکیده انگلیسی

ObjectiveTo evaluate the safety and efficacy of pregabalin in the management of chemotherapy-induced neuropathic pain in patients with childhood solid tumors and leukaemia.Materials and methodsIn an open-label study, 30 children (11 boys and 19 girls; mean age 13.5 years) who were treated for solid tumors and leukaemia, and developed a painful peripheral neuropathy, were medicated with pregabalin in the daily dose of 150–300 mg for 8 weeks.ResultsTwenty-eight patients completed the 8-week follow-up. A significant and long-lasting pain relief was noted in 86% of these patients. Median VAS score decreased by 59% at the 8th week from baseline. Adverse effects were infrequent and transient.ConclusionThe treatment with pregabalin resulted in a significant improvement in pain symptoms. The use of pregabalin in children is off-label so far. However, this drug seems to be a safe and effective remedy, which could significantly broaden the therapeutic spectrum in paediatric oncological patients suffering from neuropathic pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 13, Issue 4, July 2009, Pages 332–336
نویسندگان
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