کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3054597 1580051 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term use of botulinum toxin type A in children with cerebral palsy: Treatment consistency
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Long-term use of botulinum toxin type A in children with cerebral palsy: Treatment consistency
چکیده انگلیسی

At the University Hospital of Pellenberg (Belgium), more than 1000 patients have been treated with Botulinum toxin type A (BTX-A) over the last decade. Ten percent of these patients (n = 106) received multiple (at least four times), multi-level, high-dosage treatments. The aim of this study was to evaluate the stability of dosage and treatment intervals in long-term, multi-level, high-dosage treated children with cerebral palsy and to evaluate the evidence for a safe and stable response to this treatment. Data on disease, age, dosage and target muscles were extracted for each treatment session of 106 patients who received multiple BTX-A treatment sessions. Patients had a follow-up of 4 y 6 mo (range 1 y 8 mo–8 y 9 mo) on average and received 4 to 12 BTX-A treatments within the period of January 1996 and December 2005. Patients received a mean dosage of 23.5 ± 5.2 U/kg bw at first treatment with stable subsequent values. Mean dosages for children with diplegia, hemiplegia and quadriplegia were 24.5 ± 4.7 U/kg bw, 15.9 ± 3.7 U/kg bw and 22.0 ± 4.8 U/kg bw, respectively. Mean age at first treatment was 4 y 6 mo (range 1 y 11 mo–18 y 10 mo) with a majority of patients (76.4%) first treated within 2 and 4 y of age. Treatment intervals of approximately 1 y remained stable within four, five and six subsequent treatments. Long-term, high-dosage, multi-level BTX-A applications can be considered as a safe and stable treatment option for children with cerebral palsy and the formation of antibodies, responsible for secondary non-response, can be indirectly precluded.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 13, Issue 5, September 2009, Pages 421–429
نویسندگان
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