Diagnostic accuracy of EEG changes during carotid endarterectomy in predicting perioperative strokes

• Accuracy of intraoperative electroencephalogram (EEG) changes in predicting perioperative strokes was analyzed.
• Patients with perioperative strokes have six times greater odds of intraoperative EEG changes.
• EEG changes are more specific than sensitive in predicting perioperative strokes.

The 30 day stroke rate following carotid endarterectomy (CEA) ranges between 2–6%. Such periprocedural strokes are associated with a three-fold increased risk of mortality. Our primary aim was to determine the diagnostic accuracy of electroencephalogram (EEG) in predicting perioperative strokes through meta-analysis of existing literature. An extensive search for relevant literature was undertaken using PubMed and Web of Science databases. Studies were included after screening using predetermined criteria. Data was extracted and analyzed. Summary sensitivity, specificity and diagnostic odds ratio were obtained. Subgroup analysis of studies using eight or more EEG channels was done. Perioperative stroke rate for the cohort of 8765 patients was 1.75%. Pooled sensitivity and specificity of EEG changes in predicting these strokes were 52% (95% confidence interval [CI], 43–61%) and 84% (95% CI, 81–86%) respectively. Summary estimates of the subgroup were similar. The diagnostic odds ratio was 5.85 (95% CI, 3.71–9.22). For the observed stroke rate, the positive likelihood ratio was 3.25 while the negative predictive value was 98.99%. According to these results, patients with perioperative strokes have six times greater odds of experiencing an intraoperative change in EEG during CEA. EEG monitoring was found to be highly specific in predicting perioperative strokes after CEA.