کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3060565 | 1187452 | 2012 | 4 صفحه PDF | دانلود رایگان |
It has been found that the hemostatic system is activated following a brain injury. To explore the role of D-dimer in spontaneous intracerebral hemorrhage (ICH), this prospective study aimed to evaluate the association between serum D-dimer concentration, clinical outcome and radiographic findings of ICH patients in the emergency department (ED). Patients with acute (<24 hours) spontaneous ICH were enrolled in this study. The D-dimer concentration was related to: baseline ICH volume (r = 0.198, p = 0.01); Glasgow Coma Scale (GCS) score 3–8 (p = 0.01); GCS score 13–15 (p = 0.002); midline shift >15 mm (p = 0.016); and to subarachnoid extension of the blood (p < 0.0001). Diabetes mellitus (odds ratio [OR]: 2.93; 95% confidence interval [CI]: 1.1–7.76, p = 0.031), ICH volume (OR: 1.16; 95% CI: 1.07–1.27, p < 0.0001) and D-dimer concentration (OR: 2.72; 95% CI: 1.08–6.9, p = 0.002) were associated with 30-day mortality. This study shows that in patients with spontaneous ICH, a higher initial D-dimer concentration is associated with higher 30-day mortality.
Journal: Journal of Clinical Neuroscience - Volume 19, Issue 6, June 2012, Pages 810–813