کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3060654 | 1187454 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Characteristics of cavernomas of the brain and spine Characteristics of cavernomas of the brain and spine](/preview/png/3060654.png)
The incidence of cavernomas in the general population ranges from 0.3% to 0.5%. They frequently occur in young adults, usually being detected between the second and fifth decade of life, in both sporadic and familial forms. Patients with inherited cavernomas are typically affected by multiple lesions, whereas sporadic forms mostly present with a single lesion. Three genes responsible for development of cavernomas identified to date include CCM1, CCM2, and CCM3. The natural history of brain cavernomas is relatively benign and up to 21% of patients are asymptomatic. The most frequent manifestations of the disease are seizures, focal neurological deficits, and hemorrhage. We review the current literature data on the characteristics of brain and spinal cavernomas.
Journal: Journal of Clinical Neuroscience - Volume 19, Issue 5, May 2012, Pages 643–648