کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3060785 | 1187457 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The pathophysiological mechanisms underlying freezing of gait in Parkinson’s Disease The pathophysiological mechanisms underlying freezing of gait in Parkinson’s Disease](/preview/png/3060785.png)
Freezing of gait is a paroxysmal phenomenon most commonly found in patients with advanced Parkinson’s Disease. The pathophysiological mechanisms underlying this behaviour remain uncertain despite a well-characterised phenotype. Freezing behaviour extends beyond gait to affecting speech and upper limb function, suggesting that there is likely to be a universal mechanism underlying the phenomenon. This paper identifies the essential features required for a comprehensive model of freezing and evaluates a number of hypotheses that seek to explain the phenomenon. It appears likely that the pathophysiology of freezing involves context-dependant dysfunction across multiple levels of the neurological system, including cortical, subcortical and brainstem regions.
Journal: Journal of Clinical Neuroscience - Volume 18, Issue 9, September 2011, Pages 1154–1157