کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3061105 1187464 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of factors affecting the long-term functional outcome of patients with skull base meningioma
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Analysis of factors affecting the long-term functional outcome of patients with skull base meningioma
چکیده انگلیسی
We analyzed the factors that affect the long-term clinical outcome of a series of patients with skull base meningiomas. Clinical records of 73 patients with cranial base meningiomas were reviewed retrospectively, of whom 13 patients experienced a recurrence at various times following the initial surgery. The mean follow-up time was 90.4 ± 21.2 months (range = 60-124 months). Based on the location of the recurrence, patients with recurrence were divided into peripheral (n = 6) and central (n = 7) skull base groups. Of several variables analyzed using a multivariate logistic regression model, “high MIB-1 (Ki-67 proliferation antigen) labeling index” was an independent variable predicting poor long-term functional outcomes. Recurrence of the tumor at the central skull base was also a strong predictor of poor long-term outcomes. An increased proliferative potential, as indicated by a high MIB-1 labeling index, may induce repeated recurrences, eventually leading to worse functional outcomes, particularly for patients with central skull base meningiomas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 18, Issue 7, July 2011, Pages 895-898
نویسندگان
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