کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3061105 | 1187464 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of factors affecting the long-term functional outcome of patients with skull base meningioma
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We analyzed the factors that affect the long-term clinical outcome of a series of patients with skull base meningiomas. Clinical records of 73 patients with cranial base meningiomas were reviewed retrospectively, of whom 13 patients experienced a recurrence at various times following the initial surgery. The mean follow-up time was 90.4 ± 21.2 months (range = 60-124 months). Based on the location of the recurrence, patients with recurrence were divided into peripheral (n = 6) and central (n = 7) skull base groups. Of several variables analyzed using a multivariate logistic regression model, “high MIB-1 (Ki-67 proliferation antigen) labeling index” was an independent variable predicting poor long-term functional outcomes. Recurrence of the tumor at the central skull base was also a strong predictor of poor long-term outcomes. An increased proliferative potential, as indicated by a high MIB-1 labeling index, may induce repeated recurrences, eventually leading to worse functional outcomes, particularly for patients with central skull base meningiomas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 18, Issue 7, July 2011, Pages 895-898
Journal: Journal of Clinical Neuroscience - Volume 18, Issue 7, July 2011, Pages 895-898
نویسندگان
Naoyuki Nakao, Toshika Ohkawa, Junichirou Miki, Hiroki Nishibayahsi, Mitsuhiro Ogura, Yuji Uematsu, Toru Itakura,