کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3061384 1187470 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Frontotemporal dementia and motor neurone disease: Overlapping clinic-pathological disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Frontotemporal dementia and motor neurone disease: Overlapping clinic-pathological disorders
چکیده انگلیسی

Advances in genetics and pathology have supported the idea of a continuum between frontotemporal dementia (FTD) and motor neurone disease (MND), which is strengthened by the discovery of the trans-activating responsive (Tar) sequence DNA binding protein (TDP-43) as a key component in the underlying pathology of FTD, FTD–MND and sporadic and familial MND patients. MND is a multisystem disorder associated with cognitive and behavioural changes which in some instances reaches the criteria for FTD, while a proportion of patients with FTD develop frank MND. We review the overlap between FTD and MND, emphasizing areas of controversy and uncertainty.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 16, Issue 9, September 2009, Pages 1131–1135
نویسندگان
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