کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3061701 | 1187477 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differentiation of tumor recurrence from radiation necrosis in high-grade gliomas using 201Tl-SPECT
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
MRI is routinely performed to detect recurrence in patients with primary brain tumors, but it may not differentiate recurrent tumor from radiation-induced necrosis reliably. Thallium-201 single-photon emission computed tomography (201Tl-SPECT) might be useful in distinguishing between these two clinical entities. In a retrospective study 201Tl-SPECT studies with corresponding MRI studies in 19 patients with clinical or radiological suspicion of high-grade tumor recurrence were reviewed. The diagnostic accuracies of both modalities were based on the subsequent histology or clinical course where biopsy was not performed. Post-scan histology was available in nine patients (43%) who underwent re-resection. The SPECT result determined management in six patients (29%). Post-SPECT survival was significantly better in patients with negative 201Tl-SPECT studies compared to patients with positive studies (median survival 15 + vs. 6 months) (p = 0.04, log-rank test). The sensitivity and specificity of 201Tl-SPECT in diagnosing tumor recurrence were 83% and 100%, respectively. 201Tl-SPECT can accurately differentiate tumor recurrence from radiation necrosis in patients with high-grade gliomas and abnormal MRI findings post irradiation. This is reflected in a significantly longer post-scan survival time in patients with a negative 201Tl-SPECT result.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 15, Issue 12, December 2008, Pages 1327-1334
Journal: Journal of Clinical Neuroscience - Volume 15, Issue 12, December 2008, Pages 1327-1334
نویسندگان
Jeanne Tie, Dishan H. Gunawardana, Mark A. Rosenthal,